Lack of persistent microchimerism in contemporary transfused trauma patients
نویسندگان
چکیده
منابع مشابه
TRANSFUSION MEDICINE Brief report The TNF ( 308A) polymorphism is associated with microchimerism in transfused trauma patients
Microchimerism (MC), defined as the persistence of allogeneic cells at low concentrations, is well documented in transfused trauma patients. We hypothesized that genetic polymorphisms linked to cytokine production could contribute to trauma-induced immune modulation and development of microchimerism after transfusion of trauma patients. We used high-throughput SYBR-green-based genotyping of sin...
متن کاملThe TNF (-308A) polymorphism is associated with microchimerism in transfused trauma patients.
Microchimerism (MC), defined as the persistence of allogeneic cells at low concentrations, is well documented in transfused trauma patients. We hypothesized that genetic polymorphisms linked to cytokine production could contribute to trauma-induced immune modulation and development of microchimerism after transfusion of trauma patients. We used high-throughput SYBR-green-based genotyping of sin...
متن کاملThe impact of platelet transfusion in massively transfused trauma patients.
BACKGROUND The impact of platelet transfusion in trauma patients undergoing a massive transfusion (MT) was evaluated. STUDY DESIGN The Institutional Trauma Registry and Blood Bank Database at a Level I trauma center was used to identify all patients requiring an MT (≥10 packed red blood cells [PRBC] within 24 hours of admission). Mortality was evaluated according to 4 apheresis platelet (aPLT...
متن کاملLack of evidence for an increased microchimerism in the circulation of patients with Sjögren's syndrome.
OBJECTIVE To examine the hypothesis that fetal microchimerism plays a part in the pathogenic process of Sjögren's syndrome (SS). METHODS Genomic DNA samples were extracted from peripheral blood whole nucleated cells and the CD34+ cell enriched fraction of patients with SS and healthy women who had male offspring as well as nulliparous women. A Y chromosome-specific sequence was detected as a ...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2019
ISSN: 0041-1132,1537-2995
DOI: 10.1111/trf.15518